Brittle bone disease, or osteogenesis imperfecta, is a detrimental disorder in livestock. Calves with the condition commonly suffer multiple bone fractures in utero or at delivery, and if able to stand, have lax tendons. Depending on the cause, calves may also have blue coloration in what is otherwise the white of the eye and soft teeth. Osteogenesis imperfecta (OI) occurs in many species where it is more highly studied. In most cases, it is attributed to a new genetic mutation that occurred in the affected individual.