A large five-state, five-year study was conducted to validate the hypothesis that milk EPD truly reflects differences in weaning weight due to milk. Cows were maintained at six different locations representing relatively diverse environments throughout the southeastern quadrant of the U.S. Twenty-four Angus sires were selected for either low or high milk EPD, but with similar growth EPDs, and mated to Angus cows. The average spread in milk EPD between the low and high lines was 39 lb (-13 to +26). Lactation records for 192 daughters were used to evaluate 12-hour milk yield and weaning weight of progeny. The correlation between sires milk EPD and 12-hour milk yield was moderate to high (0.56). The difference between lines for 12 hour milk yield was 1.45 lb. The difference between low and high lines in calf weaning weight was 34 lb, which compared favorably with the spread between lines in milk EPD (39 lb). There was no statistical interaction between genetic line and location, which means that sires tended to rank similarly within each location. When milk EPDs were first published in the 1980s, there was considerable skepticism among beef producers. However, this study, along with previous studies, indicates that differences in milk EPD are reflective of differences in weaning weight between progeny (Baker et al. 2003. J. Anim. Sci. 81:1406).